The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. Many individuals with Crouzon syndrome require orthodontic treatment, often in combination with jaw surgery. This early fusion prevents the skull from growing normally and affects the shape of the head and face. The results indicate that in Crouzon syndrome the craniofacial alterations depend not only on reduced synchondrosis activity of the anterior cranial base, but also of the posterior cranial base. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. Also, sleep apnoea is an issue in both AS and CS (. It is associated with Crouzon syndrome, Angelman syndrome, as well as Fetal alcohol syndrome. Showing typical extraoral characteristics of Crouzon. Enter a Crossword Clue. We think the likely answer to this clue is. These facial deformities greatly affect the social and emotional development of the affected child. We identified a novel mutation in members of a family with signs of Crouzon syndrome and plagiocephaly. Symptoms. 8% of all craniosynostoses []. Enter the length or pattern for better results. Sort by Length. In this paper, we. (About 50% of cases of Crouzon syndrome are sporadic, with some of them having been shown to be the result of fresh mutations. Activated FGFs/FGFR2 signaling disrupts the balance of differentiation, cell proliferation, and. Enter the length or pattern for better results. Enter the length or pattern for better results. Some people could develop it due to poor dental extractions. Crouzon's syndrome is an autosomal dominant disorder with complete penetrance and variable expressivity. chromosome locus 10q25q26, which results in early fusion of the skull bones during fetal development. The tongue often falls back in the throat, causing. Cohen (1973) provided a review of all the. Specifically, this syndrome affects the first branchial (or pharyngeal) arch, which is the precursor of the maxilla and mandible. Enter a Crossword Clue. Crouzon syndrome is a genetic problem. 001 for other comparisons). Enter a Crossword Clue. The problem is often noted at birth, but it may be picked up on an ultrasound or it may not become evident until well after birth. As a result of his report, this syndrome became known as maladie de Crouzon or, more often, as Crouzon 's disease or craniofacial dysostosis. This syndrome affects around 5% of all the babies that have craniosynostosis. The manifestations of Crouzon syndrome result from the premature fusion of superior and posterior sutures of the maxilla. The syndrome was first described in 1912 by French physician Octave Crouzon when he identified both a mother and daughter with what was originally called. Crouzon syndrome is an autosomal dominant disorder characterized by craniosynostosis causing secondary alterations of the facial bones and facial structure. This early fusion prevents the skull from growing normally and affects the shape of the head and face. Lorraine Suslak proposed that the association of the three rather rare conditions (Crouzon syndrome, acanthosis nigricans and odontogenic tumors) suggested that this was a single gene disorder but did not address whether this was a rare feature of Crouzon syndrome or a distinct entity (Fig. Jaw Crossword Clue Answers. Severity of the syndrome varies from mild to severe among individuals. Sometimes surgery may be recommended as well. upper jaw do not grow in proportion to the rest of the skull. This surgery involves cutting and repositioning the upper jaw to improve how the jaws and the teeth fit together. 2 Case Report A 4-year-old female patient reported with the chief complaint of protrusion of lower jaw. Find the latest crossword clues from New York Times Crosswords, LA Times Crosswords and many more. A retrospective review was conducted for all patients affected by Crouzon syndrome who completed the entire surgical sequence. With proper treatment, these patients can be productive and active members of the main stream of society. 11. The Crossword Solver found 30 answers to "of the jaw", 7 letters crossword clue. Frequency Crouzon syndrome is seen in about 16 per million newborns. Louis E. Beare-Stevenson cutis gyrata syndrome (OMIM 123790)Crouzon Syndrome Link copied! Authors: Cynthia M. It can also be associated with Cleft lip and cleft palate. They allow the skull to expand as the child grows. Crouzon’s syndrome. Indeed, mutations in the FGFR2 gene have been detected in more than 50% of patients with Crouzon syndrome. Many children who have surgery to manage. A key feature of Crouzon is the premature closure of the skull bones, called craniosynostosis. His eye sockets were shallow causing the eyes to appear very bulging. (About 50% of cases of Crouzon syndrome are sporadic, with some of them having been shown to be the. This is a genetic syndrome that causes the seams of your skull to fuse abnormally. S. The underdeveloped middle part of. It is the main cause of the prominent characteristics of CS, such as midfacial and. The tongue often falls back in the throat, causing. Crouzon syndrome is one of the most common craniosynostosis facial syndromes caused by a mutation in the fibroblast growth factor receptor 2 (FGFR2) gene. Enter a Crossword Clue. The Crossword Solver found 30 answers to "Jaw cheek (4)", 4 letters crossword clue. Crouzon syndrome exhibits considerable phenotypic heterogeneity, in the aetiology of which genetics play an important role. Typically, the cranial vault presentation is a brachycephalic shape to the skull. Click the answer to find similar crossword clues . In children with a craniosynostosis syndrome, bones that fuse prematurely in the skull result in abnormal head shapes. Bone deformities in the middle of the face. The Crossword Solver found 30 answers to "lower jaw (4)", 4 letters crossword clue. We told the causes of crouzon syndrome then we will also tell you what’s the available treatment. This syndrome has been associated with a variety of amino acid point mutations in the extracellular domain of fibroblast growth factor receptor 2. Four children were included: three suffered from Crouzon Syndrome and one suffered from Apert Syndrome. Crouzon syndrome is the most common type of craniofacial dysostosis anomaly which presents a great challenge for clinicians since birth. The Crouzon syndrome is named after the French neurologist, Octave Crouzon, who described this disorder [1–3] which includes a triad of skull deformities, facial anomalies, and an exopthalmus [4, 5]. Click the answer to find similar crossword clues . Premature fusion of skull base leads to midfacial hypoplasia, shallow orbit, mandibular prognathism, overcrowding of upper teeth, high-arched palate, and upper airway obstruction. Crouzon syndrome, also known as craniofacial dysostosis, is a complex genetic birth disorder that may affect a child’s face, skull, and teeth. The Crossword Solver found 30 answers to "bird jaw (4)", 4 letters crossword clue. Craniofacial surgery: to create improved facial symmetry, to realign the lower and upper jaw, to establish normal joint function, to add soft tissue where needed. They affect how certain cells in the body – including bone cells – grow. If you are currently working on a puzzle and find yourself in need of a little guidance, our answer is at your service. They may have problems with teeth due to abnormal jaw. [ 2, 3] The major division among craniosynostoses is between the. Lower Jaw Part. Crouzon syndrome atau sindrom Crouzon adalah kelainan genetik yang ditandai dengan penggabungan dini tulang tengkorak tertentu ( craniosynostosis ). This is the answer to the clue : Crouzon syndrome results in lower jaw __ Figgerits. The signs and symptoms of Crouzon syndrome with acanthosis nigricans overlap with those of a similar condition called. Its mutation will therefore cause a acceleration of the ossification process of all. Today's crossword puzzle clue is a quick one: Lower jaw. Description. Results. Research has identified the affected genes as the Fibroblast Growth Factor Receptor 2 (FGFR2) gene and FRGR3. Abnormal growth of these bones leads to wide-set, bulging eyes and vision problems caused by shallow eye sockets; eyes that do not point in the same direction (strabismus);. , M. Enter the length or pattern for better results. Lower jaw Crossword Clue Answers. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. Crouzon syndrome is a genetically inherited syndrome characterized by craniosynostosis (premature fusion of coronal sutures) resulting in the skull and facial deformities. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. We found 20 possible solutions for this clue. Solve your "jaw" crossword puzzle fast & easy with the-crossword-solver. Crouzon syndrome is one of the most common craniosynostosis facial syndromes caused by a mutation in the fibroblast growth factor receptor 2 (FGFR2) gene. Crouzon syndrome is the most common form of craniofacial dysostosis, characterised by a classical triad of abnormal skull shape, abnormal facies, and exophthalmos. We found 20 possible solutions for this clue. Crouzon syndrome occurs in about one of every 100,000. Crouzon syndrome was first described nearly 100 years ago when the triad of calvarial deformities, facial anomalies, and exophthalmos was noted in a mother and her son . [1,2,3] Clinically overt dental abnormalities in these patients, usually lead them to dental. It can also be caused by inherited conditions, such as Crouzon syndrome or basal cell nevus syndrome. Small ears. Restoration of 16, 26, 36, 46, 47 was done with composite and pit and fissure sealants were applied on 44, 34, 24, 14, 15, 25; [Table/Fig-1f]. Click the answer to find similar crossword clues . Therefore, identifying Crouzon syndrome, among others syndromic craniosynostosis, can result in a diagnostic challenge. Crouzon syndrome, is a rare genetic disorder characterized by a triad of skull deformities (due to premature closure of cranial sutures: craniosynostosis), midface hypoplasia, and ocular abnormalities usually manifesting as exophthalmos. 75 × 58″) for left. With some Crouzon patients, the areas over the top of the skull, from one side to the other, at the level of the ears, may also fuse and stop growing. Enter the length or pattern for better results. In the 1990s, for example, they learned that a mutation in one gene causes Crouzon syndrome — characterized by wide-set, often bulging eyes and an underdeveloped upper jaw — while a mutation in a different gene leads to the down-slanting eyes, small lower jaw and cleft palate of Treacher Collins syndrome. Symptoms of the genetic condition include: Cleft palate. Crouzon syndrome is one of the most common craniosynostosis facial syndromes caused by a mutation in the fibroblast growth factor receptor 2 (FGFR2) gene. The lower jaw protrudes as excessive growth occurs. Calvarial suture defects may occur. Despite the reparative effects of surgeries, continued follow up is still generally required for. You can easily improve your search by specifying the number of letters in the answer. flattened cheeks curved, beak-like nose small, poorly developed upper jaw short upper lip protruding lower jaw hearing loss opening in the lip (cleft lip) or roof of the. It involves the premature fusion of sutures of the cranial vault. concave profile with an asymmetric. Children with Crouzon’s have bulging eyes due to abnormal growth of the midface. Ninety-one computed tomography scans were included (12 Asian Crouzon syndrome patients, 22. Sort by Length. headdress. Crouzon syndrome is a rare genetic disorder that may be evident at birth or during infancy. In most cases, this therapy is extensive, time-consuming, and exhausting for the patient. Mast. This study aims to conduct a comprehensive clinical and genetic investigation on a large family with members having various phenotypes, including acromesomelic dysplasia, type Maroteaux (AMDM), idiopathic short stature (ISS), Crouzon syndrome (CS). Crouzon a French neurologist first described the condition in an earlier part of the 20th century. The Crossword Solver found 30 answers to "front of lower jaw (4)", 4 letters crossword clue. 1083A>G and c. This can result in wide-set, bulging eyes. lubricating eye ointment at night; these drops can prevent the. In a child with this syndrome, premature fusion of certain skull bones ( craniosynostosis) prevents the skull from growing normally and affects the shape of the head and face; sometimes causing. 13. J Glaucoma. In most cases, this therapy is extensive, time-consuming, and exhausting for the patient. Although the mandible, or lower jaw, grows normally and because the maxilla is retruded, it causes the lower jaw to appear enlarged or more prominent. If you or a loved one is affected by this condition, visit NORD to find resources Crouzon syndrome (CS), first described in 1912 by the French neurosurgeon Octave Crouzon, is a rare genetic disorder caused by a mutation in the fibroblast growth factor receptor 2 ( FGFR2) gene. The aim of this study was to explore the difference in maxillary and mandibular morphology and spatial position in Asian and Caucasian Crouzon syndrome patients. Studies have shown that Crouzon syndrome occurs somewhere between 1 in 50,000 and 1 in 100,000 births. Crouzon syndrome is a congenital condition that is diagnosed on the basis of a specific pattern of cranial and facial malformations. Oral surgery: to align the teeth of the upper and lower jaws. It is the most common type of syndromic craniosynostosis. Ophthalmologists should be aware of the many ophthalmic associations in Crouzon syndrome and must be alert toward conditions that may require early intervention. More than 90% of Crouzon syndrome cases are caused by various mutations in the FGFR-2 gene, in which 50 unique mutations have. Please remember that I’ll always mention the master topic of the game : Figgerits Answers, the link to the previous level : Fine (syn. We think the likely answer to this clue is CHAT. Crouzon syndrome is a genetic disorder characterized by the premature fusion of certain skull bones (craniosynostosis). 1. Patients present with variable expression of the gene but appearance is characterized by protruding eyes (exorbitism), a result of the. The current literature review aims to evaluate the ocular findings and associated ophthalmic features in Crouzon syndrome. Van der Woude Syndrome This syndrome is caused by a mutation in the IRF6 gene and is a common inherited form of cleft lip and/or palate (opening in the lip and/or the roof of the mouth). Crouzon syndrome is a genetic disorder characterized by the premature fusion of certain skull bones (craniosynostosis). 2 Crouzon Syndrome . Result Crossword Clue. The Crossword Solver found 30 answers to "canines in the upper jaw (3 5)", 8 letters crossword clue. Click the answer to find similar crossword clues . The presence of prominent eyeballs, which is the characteristics of the Crouzon's disease observed. 8% of all cases of craniosynostosis. Crouzon syndrome. Enter a Crossword Clue. canines in the upper jaw (3-5) Crossword Clue. Crouzon syndrome with acanthosis nigricans has an estimated prevalence of 1 per 1,000,000 newborns. Bone deformities in the middle of the face. Clue: Lower jaw. 42 The term “Crouzon syndrome” describes an autosomal disease, which results from hereditary mutations identified in specific genes in the human DNA chain. 8% of all cases of craniosynostosis. Both can cause an underdeveloped jaw and crowded teeth. Mandibular growth has been reported to be normal in. Illustrative. See full list on my. Surgical. Ophthalmological and radiological picture of Crouzon syndrome Gordana Stanković-Babić et al. Differential Diagnoses. Patient care necessitates multifaceted specialization and management. wide-set, bulging eyes. Click the answer to find similar crossword clues . Sometimes symptoms may be more severe in babies than in others. This case report illustrates a temporally coordinated therapy plan that succeeds in reducing the burden of care. Mast. Crouzon syndrome is one of the most common craniofacial syndromes and is inherited as autosomal dominant with variable expression. Gorry MC, Preston RA, White GJ, Zhang Y, Singhal VK, Losken HW, Parker MG, Nwokoro NA, Post JC, Ehrlich GD. The patient was referred to pediatrician for detailed examination and confirmation of diagnosis. which results in problems with alignment of the upper and lower teeth. A genetic condition - FGFR2 gene mutation on chromosome 10 (Crouzon syndrome, 2010) Premature skull fusion (Crouzon's syndrome, 2006) 1 in 10,000 births in U. The therapy of patients with Crouzon syndrome involves a multidisciplinary team. It involves the premature fusion of sutures of the cranial vault. Clue Enter length and letters 2. More procedures continued as Danner grew. Infants have sutures between the bones in the face and skull. How Is a Malocclusion of the Teeth Treated? The vast majority of malocclusion conditions will require no. Abstract. Premature fusion of the skull bones prevents the skull from growing normally and affects the shape of the child’s head and face. igenetics also plays an important role in Crouzon syndrome [2,4]. His oral hygiene was poor with crowding of upper and lower teeth, reverse over-jet with posterior crossbite and anterior open bite (Fig. ) Figgerits and the link to the main level Figgerits answers level 28. 13. Downward slanting eyes (down-slanting palpebral fissures). Enter the length or pattern for better results. Many features of Crouzon syndrome result from the premature fusion of the skull bones. However, recent. This term means that at least one of a person's skull bones fuses prematurely. This means premature fusion of the fibrous joints (called. overcrowding of upper and lower teeth, and V-shaped maxillary dental arch. We will try to find the right answer to this particular crossword clue. useless. The severity of these signs and symptoms varies among affected people. The most common craniosynostosis syndromes are Crouzon, Pfeiffer and Apert. Crouzon syndrome with acanthosis nigricans is found in an estimated 5-10% of all Crouzon cases, it is very rare. Enter a Crossword Clue. rare in Crouzon syndrome. Crouzon syndrome is a rare genetic condition affecting primarily the skull and facial bones. 5. Editor-In-Chief: C. 14, 23 and 24 was done in the upper arch to provide space for alignment. If necessary, mid-facial advancement and jaw surgery can be done to provide adequate orbital. Additionally, this disorder may present with premature fusion of multiple sutures, maxillary hypoplasia, and shallow orbits. twist. Click the answer to find similar crossword clues . Enter a Crossword Clue. 13), which was deeper than that. The hallmarks of Crouzon syndrome are overcrowding of upper and lower teeth, V-shaped maxillary dental arch, and bulging mandible (lower jaw). Early fusion of the skull bones prevents the skull from. It was last seen in The Daily Telegraph quick crossword. Cycloplegic refraction was +1. Mayo Clinic notes this type of procedure is appropriate for children once their jaw growth stops, at about 14 to 16 years of age for females and 17 to 21 for males. Cranial sutures or anatomical lines are the fibrous tissue bands that join the. Over time their upper jaw may look smaller and the lower jaw may stick out (underbite). Abstract. There are related clues (shown below). PubMed ID: 29557836. Crouzon syndrome is characterized by craniosynostosis and facial dysostosis with an incidence of 16. 7 Crouzon patients (4 females, 3 males). 5/1,000,000, accounting for 4. Inheritance is autosomal dominant, resulting from mutations in the Ig II-III linker region of the FGFR2 gene. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. Enter the length or pattern for better results. 4. S. Crossword Clue" Puns Are A Rare Medium Well Done" (Dad Joke) Crossword Clue;. Crouzon syndrome is a genetic disorder characterized by the premature fusion of certain skull bones (craniosynostosis). Crouzon syndrome belongs to a large and heterogeneous group of conditions presenting with craniosynostosis, a common symptom of which is early fusion of one or more cranial sutures. See more answers to this puzzle’s clues. FGFR2 mediates extracellular signals into cells and the mutations in the FGFR2 gene cause this syndrome occurrence. Learn about your child's treatment options at UPMC Children's Hospital . Crouzon syndrome is considered as one of the most common craniosynostosis syndromes with a prevalence of 1 in 65,000 individuals, and has a close relationship with variants in fibroblast growth factor receptor 2. This gene is involved in controlling the production of proteins responsible for bone development and growth. The fat was reinjected at the level of the infraorbital rim, the nasolabial fold or the palpebrojugal fold, in the different planes, according to the patients’ needs. The babies that have Crouzon syndrome can present the following symptoms: • Bulging eyeballs • Enlarged foreheadCrouzon syndrome is a genetic condition that results in an abnormal fusion of some of the bones of the skull and face that does not allow the bones to grow normally, affecting the shape of the head, the appearance of the face and the relationship of the teeth. This also allows for the proper alignment of the upper jaw (maxilla) and the lower jaw (mandible) in older patients. Crouzon syndrome (OMIM: 123500) is caused by mutations in FGFR2, mapped to chromosome locus 10q26. org This condition is known as exophthalmos. Crouzon’s syndrome is caused by mutation in the fibroblast growth factor receptor 2 (FGFR2) gene. Some of the symptoms of Crouzon Syndrome are. 42 The term “Crouzon syndrome” describes an autosomal disease, which results from hereditary mutations identified in specific genes in the human DNA chain. []The most notable characteristic of Crouzon Syndrome is cranial synostosis (a union between. Missing or malformed thumbs. Crouzon syndrome is usually the mildest of the FGFR2-associated disorders and the clinical diagnosis is suggested by the combination of crouzonoid facies and absence of major abnormalities of the. Crouzon Syndrome describes a combination of birth defects that occur as the result of a mutation of one of the genes at the time of conception. How Fashion Lets Me Embrace the Physical Differences Caused by Crouzon Syndrome. Figure 3. We have the answer for Tip of lower jaw crossword clue in case you’ve been struggling to solve this one! Crosswords can be an excellent way to stimulate your brain, pass the time, and challenge yourself all at once. This syndrome results in wide-set, bulging eyes, an underdeveloped upper jaw, and a beaked nose due to the head being unable to grow normally. Craniosynostosis, or premature fusion of the cranial sutures, is the basic identifiable characteristic of a patient who has Crouzon syndrome (sometimes called craniofacial dysostosis). After surgery, distraction osteogenesis enlarges the lower jaw. The 14-yr-old boy had an abnormally shaped skull & face. Solve your "lower jaw" crossword puzzle fast & easy with the-crossword-solver. Click the answer to find similar crossword clues . The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. 4:1 has been reported. Figgerits Answers and Cheats. Enter a Crossword Clue. 1 Definition . Described by a French neurosurgeon in 1912, it is a rare genetic disorder. The Crossword Solver found 30 answers to "jutting part of lower jaw (4)", 4 letters crossword clue. Introduction. point of the jaw (4) Crossword Clue. Click the answer to find similar crossword clues . This prevents normal growth of the skull, which can affect the shape of the head and face. Last Seen Crosswords. Mustafa Awad, of Iraq was diagnosed with Crouzon Syndrome. Crouzon syndrome. C342Y) in the FGFR2 receptor, are viable and fertile and are characterised by brachycephaly caused. Here are the possible solutions for "Lower jaw" clue. Crouzon syndrome is an autosomal dominant condition primarily characterized by craniosynostosis. shallow mid-face, which may lead to breathing difficulties. . protruding lower jaw overcrowded teeth These facial abnormalities are a result of the following: Craniosynostosis: Premature (early) closure of growth plates of the skull that. Apert syndrome treatments include: Eyedrops during the day, with. 1. It is important for anesthesiologists managing such patients. 1 Definition . A core category emerged labelled. The Fgfr2cC342Y/+ Crouzon syndrome mouse model carries a cysteine to tyrosine substitution at amino acid position 342 (Cys342Tyr; C342Y) in fibroblast growth factor receptor 2 (FGFR2), equivalent to the FGFR2 mutation commonly associated with Crouzon syndrome. Enter the crossword clue and click "Find" to search for answers to crossword puzzle clues. The mean age at the time of review was 11. Review the clinical features of Crouzon syndrome. [1,4] The. Outline the workup of Crouzon syndrome and describes the role of health professionals working together to manage this condition. It occurs due to mutation in fibroblast growth factor receptor II (FGFR-2) gene mapped on the chromosome loci 10q25-10q26. A positive result should prompt a careful neurosurgical assessment as hydrocephalus is a frequent association. Crouzon syndrome, also known as craniofacial dysotosis, is rare disorder characterized by premature craniosynostoses. Crouzon syndrome is a genetic congenital condition characterized by skeletal and facial malformations. Without the typical ossification of the sutures in the first year of life, the diagnosis of Crouzon syndrome may be delayed, as in this case. Most cases are sporadic, but autosomal dominant inheritance has been reported ( Mantilla-Capacho et al. And Down syndrome makes an extra. The incidence of the disease significantly increases with paternal age and is felt to provide a selective advantage within the male spermatogonial cells. It is a letter guessing game where you have to find phrases. Thus your lower jaw also grows extensively, causing Mandibular Prognathism. Crouzon syndrome with acanthosis nigricans is found in an estimated 5-10% of all Crouzon cases, it is very rare. The purpose of this study is to trace an operative algorithm with a long term follow up in a homogenous group of patients affected by Crouzon syndrome. lip are some described abnormalities. Activated FGFs/FGFR2 signaling disrupts the balance of differentiation, cell proliferation, and. Crouzon syndrome is a genetic disorder characterized by the premature fusion of certain skull bones (craniosynostosis). Crouzon syndrome with acanthosis nigricans is a disorder characterized by the premature joining of certain bones of the skull (craniosynostosis) during development and a skin condition called acanthosis nigricans. We will try to find the right answer to this particular crossword clue. ) New mutation – 25 to 50% of cases (Head, 2010) Autosomal Dominant (Crouzon syndrome, 2010) 50% probability of transfer to offspring. Crouzon, in 1912. The cranial deformity in Crouzon syndrome that arises out of bilateral coronal suture fusion appears as turribrachycephaly or may result from fusion of sagittal and lambdoid sutures (Crouzon, 1912). The crossword clue Result with 7 letters was last seen on the November 18, 2023. Result - crossword puzzle clues and possible answers. Click the answer to find similar crossword clues . The child may have trouble closing the eyes completely. Clue: Lower jaw. Phenotypic expression in humans exhibits an autosomal dominant pattern that commonly involves premature fusion of the coronal suture (craniosynostosis) and severe midface. His eye sockets were shallow causing the eyes to appear very bulging. Crouzon syndrome was made on the basis of clinical, ocular, and radiological findings. It is associated with Crouzon syndrome, Angelman syndrome, as well as Fetal alcohol syndrome. There are other effects of this condition and ways to manage. Goriely et al. While Mendelian craniofacial defects are well characterized (e. Such abnormalities may vary greatly in range and severity from case to case, including variations among affected family members. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. Children with Crouzon syndrome may have one or more of these symptoms: Misshapen head: wide across the front and short from front to. Upper jaw. In a child with this syndrome, premature fusion of certain skull bones ( craniosynostosis) prevents the skull from growing normally and affects the shape of the head and face; sometimes causing. There are around 200 known craniosynostosis syndromes. Click the answer to find similar crossword clues .